An overview of fatigue and associated conditions in hypermobile EDS, hypermobility spectrum disorder, as well as prevalence data in other subtypes from other studies. Symptoms of dysautonomia were very common, with fatigue, dizziness, and brain fog being the most frequently reported. Heart palpitations and thermoregulatory dysfunction were also common, indicating significant autonomic involvement in both groups. Despite the high burden of symptoms, many hEDS participants and

Dissertation by Kathryn Byerly The heart's development and its malfunction in disease share many underlying biological processes, but we don't fully understand how. This gap makes it difficult to develop new treatments. This dissertation uses mouse models to study two questions: how the heart forms normally, and how it gets damaged during disease.   The main focus to understand development is a protein called DCHS1, which helps cells "know" their position in an organ and comm

Our lunch & learn, “Is it Really That Rare? Rethinking hEDS in Everyday Practice,” brought together a room full of future clinicians ready to improve how Ehlers-Danlos syndrome is understood and treated. Dr. Norris introduced the Ehlers-Danlos syndromes, a group of connective tissue disorders that share the feature of joint hypermobility, skin hyperextensibility, and tissue fragility. The subtypes have distinct features and are separated both phenotypically and genetically, a

What is hypermobile Ehlers-Danlos Syndrome: What We Know Based on Recent Studies Recent publications from the Norris Lab have provided striking insights and new research directions to better define and understand the pathophysiology of hypermobile Ehlers-Danlos syndrome. These studies support one of our main objectives at the Norris Lab: to investigate the genetic and biological drivers of hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders to advance scie

"INSPIRING AND HEART-WRENCHING!" – Kent Hill, Film Threat   “A FASCINATING MEDICAL MYSTERY... AN AMAZING PIECE OF STORYTELLING!” – Matt Carey, Deadline Hollywood "A HEARTBREAKING WAKE-UP CALL AND A RALLYING CRY FOR CHANGE.” – Tom Needham, Film Sounds Hear an update from the producers of Complicated, a new documentary about EDS and the challenges families of sick children go through in the medical system!   "It's been a whirlwind several months as  COMPLICATED  took to the cam

Cardiac researchers Kathryn Byerly and Cayla Wolfe were world travelers this month, traveling across the nation and all the way to South...