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EDS Mouse Model Repository

Advancing New Frontiers in EDS Research

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At the Norris lab, we are dedicated to accelerating the understanding of all subtypes of EDS. Through our mouse repository, we aim to provide researchers worldwide with access to genetically accurate EDS mouse models generated using CRISPR-Cas9 technology.

We believe that providing the tools for new researchers to enter the field will lead to accelerated new discoveries, additional funding opportunities, and innovative care for patients.

To accelerate discovery,
these mouse models are provided FREE
to eligible researchers

Why Mouse Models Matter

Ehlers-Danlos Syndrome is a complex group of connective tissue disorders that can manifest in various ways. Understanding the biomechanical and molecular underpinnings of EDS is vital to develop effective treatments. Mouse models play a pivotal role in this process by allowing scientists to:

  • Mimic Human Conditions: Create accurate representations of specific EDS subtypes in mice, enabling researchers to study the disease in a controlled environment.

  • Uncover Disease Insights: Study the biology that drives EDS, shedding light on its mechanisms and potential pathways for intervention.

  • Test Therapies: Evaluate potential treatments and interventions, laying the foundation for clinical trials and targeted therapies.

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How Researchers Can Benefit

Our repository is designed to increase the number of scientists and institutions dedicated to EDS studies. Researchers can:

  • Access Ready-Made Models: Free access to all KI models and potentially cell lines for each EDS subtypes from a one-stop shop. Sperm and/or embryos can be shipped globally.

  • Collaborate: Connect with fellow researchers and institutions to share insights and accelerate discoveries.

  • Contribute Data: Share your findings and contribute to the collective knowledge pool to advance EDS research further.

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What Subtypes Are Available

Our repository will include all subtypes of EDS incorporating a specific known 

genetic variation. These subtypes and genes include:

  • Classical EDS (cEDS): COL5A1

  • Classical-like EDS Type 1 & 2 (clEDS): AEBP1

  • Cardiac-vavlular (cvEDS): COL1A2

  • Vascular EDS (vEDS): COL3A1

  • Hypermobile EDS (hEDS): Pending

  • Arthrochalasia EDS (aEDS): COL1A1, COL1A2

  • Dermatosparaxis EDS (dEDS): ADAMTS2

  • Kyphoscoliotic EDS (kEDS): FKBP14

  • Brittle Cornea Syndrome (BCS): ZNF469

  • Spondylodysplastic EDS (spEDS): B3GALT6

  • Musculocontractural EDS (mcEDS): CHST14

  • Myopathic EDS (mEDS): COL12A1

  • Periodontal EDS (pEDS): C1R

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Interested
in learning more?
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