The Norris Lab
Advancing the cycle of discovery
Dr. Russell "Chip" Norris, PhD
Dr. Norris has 25 years of experience understanding the genetic and developmental causes of syndromic and non-syndromic cardiovascular diseases including mitral valve prolapse, aortic stenosis, bicuspid aortic valve diseases and cardiomyopathies. Recently, his lab identified a strong candidate gene for hypermobile Ehlers-Danlos syndrome (hEDS). Armed with the one of the largest global clinical registry and the first animal model for hEDS, the lab is is working to translate genetic discoveries into diagnostic screens and treatments for children and adult hEDS patients.
Our Current Work
The Norris lab is a multidisciplinary environment with students, technicians, and postdocs using molecular, biochemical and biomechanical tools to understand common and rare connective tissue diseases.
In the News
Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis
Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP.