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The Norris Lab

Advancing the cycle of discovery

Dr. Russell "Chip" Norris, PhD
Principal Investigator

Dr. Norris has 25 years of experience understanding the genetic and developmental causes of syndromic and non-syndromic cardiovascular diseases including mitral valve prolapse, aortic stenosis, bicuspid aortic valve diseases and cardiomyopathies. Recently, his lab identified a strong candidate gene for hypermobile Ehlers-­Danlos syndrome (hEDS). Armed with the one of the largest global clinical registry and the first animal model for hEDS, the lab is is working to translate genetic discoveries into diagnostic screens and treatments for children and adult hEDS patients.

Our Current Work

The Norris lab is a multidisciplinary environment with students, technicians, and postdocs using molecular, biochemical and biomechanical tools to understand common and rare connective tissue diseases. 

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Cardiac Research

Mitral Valve Prolapse, Fibrosis, Valve Development


EDS Research

Molecular & Mechanical Basis of Ehlers-Danlos Syndrome


Patient Scientist Initative

Developing the next generation of EDS experts


Mouse Model Repository

Advancing understanding of all subtypes of EDS 

In the News

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CNN Article Featuring the Norris Lab One of CNN's "Top 100 Digital Stories" for 2022

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Dr. Norris Named to $8 Million Leducq Grant Initiative Studying Acute Rheumatic Fever (ARF)

Selected Publications

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Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP.

Find a complete list of publications by the Norris lab
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